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Real Madrid's midfield engine will stay at Valdebebas after a derby tackle left him with a serious ankle problem.
Valverde finished the derby despite severe left-ankle trauma, leaving his Uruguay window hanging on further tests.
A defensive howler handed Wolves derby bragging rights at Molineux.
The Black Country derby is back for the first time since 2024, with Wolves hosting at Molineux.
Wolves host West Brom in a Championship showdown, with live coverage on Sky Sports.